The Finalists

3D histology made easy. Clepio Biotech opens a new dimension for cancer understanding and diagnosis, offering an innovative and automated service for 3D reconstruction and analysis of tissue biopsies, compliant with the quality and process standards required for clinical use and achieving more reliable quantification of histological immunotherapy biomarkers

EsoSoft is a minimally invasive and soft device for the timely treatment under mechanotherapy of the esophageal atresia (EA), a congenital abnormality in which the esophagus is disconnected from the stomach at birth, preventing baby feeding from the mouth and currently treated with invasive and extremely risky surgical procedures.

Fama Labs is a digital health company dedicated to enhancing therapeutic adherence through innovative technology. Its flagship product, Meditype, is a configurable, voice-enabled AI companion designed to support patients in their therapeutic journeys, maximizing engagement and adherence, reducing healthcare costs, and providing valuable data insights.

Medical FLOWeR is developing an innovative medical device for extracorporeal organ preservation, offering advanced features compared to traditional methods, such as multi-configuration, both normothermic and hypothermic perfusion, a wide range of integrated biosensors, ensuring a comprehensive control of the preservation process, thus allowing the increase of transplant success rates

INTA develops and commercialize portable diagnostic devices. Its flagship product is the NanoAnalyzer, a portable, lab-on-a-chip design, AI-powered multiplexed biosensing system for the diagnosis of mild traumatic brain injuries (TBI) through cost-effective and very rapid blood analysis in respect to expensive and time-consuming CT scans

Microvaxxine is developing innovative antitumor vaccines based on antigens derived from viruses and bacteria (MoAs) with high homology to multiple tumor antigens (TAAs), able to elicit a potent immune response, cross-reacting with the highly similar TAAs and killing tumor cells. First target is hepatocellular carcinoma (close to start phase 1), but the proposed approach can be effective against multiple tumors.

Often Medical developed a novel system for guiding needles and catheters into the epidural space, used for loco-regional anesthesia, pain therapy and spinal cord stimulators implantation, based on optical fiber probe measuring the force exerted on the epidural needle tip during tissue penetration, giving the physician a visual and acoustic feedback during the procedure, thus making identification of correct epidural needle placement fully reliable and accurate.

PoliRNA develops novel hybrid nanocarriers for a new generation of RNA therapies, overcoming the limited stability, safety and lack of cell-targeting efficiency of gold-standard lipid nanoparticles (LNPs). First focus is cardiac regenerative medicine, with the developed NPs showing enhanced properties in preclinical trials, paving the way towards novel applications of RNA therapies in that and other fields.

Previeni has developed a patented portable hardware device based on electromagnetic imaging enhanced by AI software, providing quantification of water in the lungs (current methods provide information in only 4% of cases), that can be integrated in the current radiographic flow to avoid misdiagnosis, generating anatomical images providing information on fluid concentrations, their movement, tissues or foreign objects.

ScarTech innovative solution is a biomedical device with modulated compression to optimize skin scar healing, enhancing tissue repair following brachioplasty. The device applies mechanical loads to provide a dual compression effect on the scar, being customizable towards different anatomical districts, optimizing the scar healing process and preventing hypertrophic and keloidal healing, maximizing the aesthetic and functional results of wound healing.

UNICORN has developed its first prototipe, USe (Ultrasound Steatosis Evaluator), an AI-based advanced, cost-effective and rapid diagnostic solution for liver steatosis (the most common liver disease) in ultrasound, able to analyze a single US image and evaluate accurately the presence of fat above 7% in liver (current US limit is <19%), similarly to the MRI gold standard.